Article
The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.
The Journal of experimental medicine - 20 Jan 1997
Tumas-Brundage K, Manser T
Abstract excerpt
A somatic process introduces mutations into antibody variable (V) region genes at a high rate in many vertebrates, and is a major source of antibody diversity. The mechanism of this hypermutation process remains enigmatic, although retrospective studies and transgenic experiments have recently su...
Topics
- Animals
- Base Sequence
- DNA
- Founder Effect
- Immunoglobulin Heavy Chains
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Transcription, Genetic