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Article

The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.

The Journal of experimental medicine - 20 Jan 1997

Tumas-Brundage K, Manser T

Abstract excerpt

A somatic process introduces mutations into antibody variable (V) region genes at a high rate in many vertebrates, and is a major source of antibody diversity. The mechanism of this hypermutation process remains enigmatic, although retrospective studies and transgenic experiments have recently suggested a role for transcriptional regulatory elements. Here, we demonstrate that mouse heavy (H) chain loci in which...

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Identifiers

PMID: 9016873
DOI: 10.1084/jem.185.2.239
PMCID: PMC2196128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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