Article
Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibility.
Diabetes - 1 Apr 2005
Davis Richard C, Schadt Eric E, Cervino Alessandra C L, Péterfy Miklós, Lusis Aldons J
Abstract excerpt
The inbred mouse strain C57BLKS/J (BKS) carrying a mutation of the leptin receptor lepr(-/-) (BKS-db) is a classic mouse model of type 2 diabetes. While BKS was originally presumed to be a substrain of C57BL/6J (B6), it has become apparent that its genome contains introgressed regions from a DBA/2 (DBA)-like strain and perhaps other unidentified sources. It has been hypothesized that the strikingly enhanced...
Topics
- Animals
- Arteriosclerosis
- Chromosome Mapping
- Diabetes Mellitus
- Genetic Predisposition to Disease
- Genotype
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Polymorphism, Single Nucleotide
- Receptors, Cell Surface
- Receptors, Leptin