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Article

mdm-2 expression correlates with wild-type p53 status in esophageal adenocarcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jun 1999

Soslow R A, Altorki N K, Yang G, Xie D, Yang C S

Abstract excerpt

Several immunohistochemical studies showed that p53 protein is expressed in 50 to 80% of esophageal adenocarcinomas (EAs). Mutations of this tumor suppressor gene are present in 40 to 70% of EAs, so it is possible that p53 expression might occur as a result of mechanisms other than gene mutation. The human homologue of the murine double minute-2 gene (mdm-2) is a known regulator of p53 activity, and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

Share to Proto-Oncogene Proteins c-mdm2

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PMID: 10392633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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