Article
Correlation of p53 mutations with epidermal growth factor receptor overexpression and absence of mdm2 amplification in human esophageal carcinomas.
Molecular carcinogenesis - 1 Jan 1993
Esteve A, Lehman T, Jiang W, Weinstein I B, Harris C C, Ruol A, Peracchia A, Montesano R, Hollstein M
Abstract excerpt
Esophageal carcinomas from 24 patients, most of whom were smokers and consumed alcoholic beverages daily, were analyzed for mutations in exons 5-8 of the p53 tumor suppressor gene. Mutations were identified by polymerase chain reaction amplification and direct sequencing in 12 of 24 (50%) of the...
Topics
- Carcinoma, Squamous Cell
- ErbB Receptors
- Esophageal Neoplasms
- Female
- Gene Amplification
- Genes, Retinoblastoma
- Genes, myc
- Genes, p53
- Humans
- Immunohistochemistry
- Male
- Mutation
- Neoplasm Proteins