Article
Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer.
Oncogene - 24 Jun 1999
Lee S H, Shin M S, Park W S, Kim S Y, Kim H S, Han J Y, Park G S, Dong S M, Pi J H, Kim C S, Kim S H, Lee J Y, Yoo N J
Abstract excerpt
Fas (Apo-1/CD95) is a cell-surface receptor involved in cell death signaling. The key role of the Fas system in negative growth regulation has been studied mostly within the immune system, and somatic mutations of Fas gene in cancer patients have been described solely in lymphoid-lineage malignancies. However, many non-lymphoid tumor cells have been found to be resistant to Fas-mediated apoptosis, which suggests...
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