Article
Mutation of CD95 (Fas/Apo-1) gene in adult T-cell leukemia cells.
Blood - 15 May 1998
Tamiya S, Etoh K, Suzushima H, Takatsuki K, Matsuoka M
Abstract excerpt
CD95 antigen (also known as Fas or Apo-1) and Fas ligand play key roles in apoptosis of cells of the immune system, function as effector molecules of cytotoxic T lymphocytes, and function in the elimination of activated lymphocytes during the downregulation of the immune response. The critical roles of the Fas-Fas ligand system in apoptosis suggest that its inactivation may be involved in malignant...
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