Article
Alterations of Fas (APO-1/CD 95) gene and its relationship with p53 in non small cell lung cancer.
Oncogene - 4 Oct 2001
Boldrini L, Faviana P, Pistolesi F, Gisfredi S, Di Quirico D, Lucchi M, Mussi A, Angeletti C A, Baldinotti F, Fogli A, Simi P, Basolo F, Fontanini G
Abstract excerpt
The Fas (APO-1/CD95) system regulates a number of physiological and pathological processes of cell death. The ligand for Fas induces apoptosis by interacting with a transmembrane cell surface Fas receptor. The key role of the Fas system has been studied mostly in the immune system, but Fas mutations, one of the possible mechanisms for resistance to apoptosis signaling, may be involved in the pathogenesis of...
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