Article
p16/pRb pathway alterations are required for bypassing senescence in human prostate epithelial cells.
Cancer research - 15 Jun 1999
Jarrard D F, Sarkar S, Shi Y, Yeager T R, Magrane G, Kinoshita H, Nassif N, Meisner L, Newton M A, Waldman F M, Reznikoff C A
Abstract excerpt
The cell cycle regulatory genes p16/CDKN2 and RB are frequently deleted in prostate cancers. In this study, we examined the role of alterations in p16 and pRb during growth, senescence, and immortalization in vitro of human prostate epithelial cells (HPECs). HPECs are established from normal prostate tissues and cultured on collagen-coated dishes. Our results show that p16 is reproducibly elevated at senescence...
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