Phenotypic characterization of immortalized normal and primary tumor-derived human prostate epithelial cell cultures.

doi:10.1002/1097-0045(20000701)44:2<164::aid-pros9>3.0.co;2-4

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Article

Phenotypic characterization of immortalized normal and primary tumor-derived human prostate epithelial cell cultures.

The Prostate - 1 Jul 2000

Schwab T S, Stewart T, Lehr J, Pienta K J, Rhim J S, Macoska J A

Abstract excerpt

BACKGROUND: Cell lines can provide powerful model systems for the study of human tumorigenesis. However, the human prostate cancer cell lines studied most intensively by investigators (PC3, DU145, and LNCaP) were established from metastatic lesions, and it is unlikely that they accurately recapitulate the genetic composition or biological behavior of primary prostate tumors. Cell lines more appropriate for the...

Topics

Animals
Cell Division
Cell Line, Transformed
Culture Media, Serum-Free
Epithelial Cells
Humans
Immunohistochemistry
Indicators and Reagents
Male
Metribolone
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Nude

Papillomaviridae

Phenotype

Prostate

Prostatic Neoplasms

Simian virus 40

Testosterone Congeners

Source

Open in PubMed

Identifiers

PMID: 10881026
DOI: 10.1002/1097-0045(20000701)44:2<164::aid-pros9>3.0.co;2-4

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