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Article

Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts.

Molecular and cellular biology - 1 Sept 2000

Dulić V, Beney G E, Frebourg G, Drullinger L F, Stein G H

Abstract excerpt

Irreversible G(1) arrest in senescent human fibroblasts is mediated by two inhibitors of cyclin-dependent kinases (Cdks), p21(Cip1/SDI1/WAF1) and p16(Ink4A). To determine the physiological and molecular events that specifically require p21, we studied senescence in human diploid fibroblasts expressing the human papillomavirus type 16 E6 oncogene, which confers low p21 levels via enhanced p53 degradation. We show...

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Identifiers

PMID: 10958672
DOI: 10.1128/MCB.20.18.6741-6754.2000
PMCID: PMC86196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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