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Article

Overcoming cellular senescence in human cancer pathogenesis.

Genes & development - 15 Jan 1998

Yeager T R, DeVries S, Jarrard D F, Kao C, Nakada S Y, Moon T D, Bruskewitz R, Stadler W M, Meisner L F, Gilchrist K W, Newton M A, Waldman F M, Reznikoff C A

Abstract excerpt

Elevation of p16, the CDKN2/p16 tumor suppressor gene (TSG) product, occurs at senescence in normal human uroepithelial cells (HUC). Immortal HUCs and bladder cancer cell lines show either alteration of p16 or pRb, the product of the retinoblastoma (RB) TSG. In addition, many human cancers show p16 or pRb alteration along with other genetic alterations that we associated with immortalization, including +20q and...

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Identifiers

PMID: 9436977
DOI: 10.1101/gad.12.2.163
PMCID: PMC316442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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