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Article

Novel Pathways Associated with Bypassing Cellular Senescence in Human Prostate Epithelial Cells

1 Apr 2002

Abstract excerpt

Cellular senescence forms a barrier that inhibits the acquisition of an immortal phenotype, a critical feature in tumorigenesis. The inactivation of multiple pathways that positively regulate senescence are required for immortalization. To identify these pathways in an unbiased manner, we performed DNA microarray analyses to assess the expression of 20,000 genes in human prostate epithelial cells (HPECs) passaged...

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PMID: 11836256
DOI: 10.1074/jbc.m200373200

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