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Article

Immortalization of human prostate epithelial cells by HPV 16 E6/E7 open reading frames

1 Aug 1999

Abstract excerpt

BACKGROUND: The exact pathogenesis for prostate cancer is not known. Progress made in prostate cancer research has been slow, largely due to the lack of suitable in vitro models. Here, we report our work on the immortalization of a human prostate epithelial cell line and show that it can be used as a model to study prostate tumorigenesis. METHODS: Replication-defective retrovirus harboring the human...

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PMID: 10398276
DOI: 10.1002/(sici)1097-0045(19990801)40:3<150::aid-pros2>3.0.co;2-7

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