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Article

The coactivator CRTC1 promotes cell proliferation and transformation via AP-1

21 Jan 2009

Abstract excerpt

Regulation of gene expression in response to mitogenic stimuli is a critical aspect underlying many forms of human cancers. The AP-1 complex mediates the transcriptional response to mitogens, and its deregulation causes developmental defects and tumors. We report that the coactivator CRTC1 cyclic AMP response element-binding protein (CREB)-regulated transcription coactivator 1 is a potent and indispensable...

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PMID: 19164581
DOI: 10.1073/pnas.0808749106

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