Article
Urokinase expression and binding activity associated with the transforming growth factor beta1-induced migratory and invasive phenotype of mouse epidermal keratinocytes.
Journal of cellular biochemistry - 1 Jul 1999
Santibáñez J F, Frontelo P, Iglesias M, Martínez J, Quintanilla M
Abstract excerpt
Transforming growth factor beta1(TGF-beta1) is a stimulator of malignant progression in mouse skin carcinogenesis. TGF-beta1 exerts a differential effect on cultured nontumorigenic (MCA3D cell line) and transformed (PDV cell line) keratinocytes. Whereas MCA3D cells are growth arrested and committed to die in the presence of the factor, it induces a reversible epithelial-fibroblastic conversion in PDV cells. This...
Topics
- Amino Acid Sequence
- Animals
- Cell Line, Transformed
- Cell Movement
- Culture Media, Conditioned
- Epidermis
- Humans
- Keratinocytes
- Mice
- Molecular Sequence Data
- Phenotype
- Protein Binding
- Skin Neoplasms
- Transforming Growth Factor beta