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Article

Inhibition of migration and invasion of carcinoma cells by urokinase-derived antagonists of alphavbeta5 integrin activation.

International journal of cancer - 15 Jan 2009

Vocca Immacolata, Franco Paola, Alfano Daniela, Votta Giuseppina, Carriero Maria Vincenza, Estrada Yeriel, Caputi Mario, Netti Paolo A, Ossowski Liliana, Stoppelli Maria Patrizia

Abstract excerpt

We previously showed that, while binding to urokinase receptor (uPAR) through its growth factor domain (GFD, residues 1-49), urokinase (uPA) can engage alphavbeta5 integrin through an internal domain (CP, residues 132-158). This novel uPA/alphavbeta5 interaction promotes cytoskeletal rearrangements and directional cell migration (Franco et al., J Cell Sci 2006;119:3424-34). We now show that treatment of cells...

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Identifiers

PMID: 18844213
DOI: 10.1002/ijc.23933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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