Article
Autophagy genes are essential for dauer development and life-span extension in C. elegans.
Science (New York, N.Y.) - 5 Sept 2003
Meléndez Alicia, Tallóczy Zsolt, Seaman Matthew, Eskelinen Eeva-Liisa, Hall David H, Levine Beth
Abstract excerpt
Both dauer formation (a stage of developmental arrest) and adult life-span in Caenorhabditis elegans are negatively regulated by insulin-like signaling, but little is known about cellular pathways that mediate these processes. Autophagy, through the sequestration and delivery of cargo to the lysosomes, is the major route for degrading long-lived proteins and cytoplasmic organelles in eukaryotic cells. Using...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.