Article
Relevance of interleukin 1 receptor antagonist intron 2 polymorphism in Italian MS patients.
Neurology - 10 Jun 1999
Sciacca F L, Ferri C, Vandenbroeck K, Veglia F, Gobbi C, Martinelli F, Franciotta D, Zaffaroni M, Marrosu M, Martino G, Martinelli V, Comi G, Canal N, Grimaldi L M
Abstract excerpt
The A1/A1 genotype of the anti-inflammatory cytokine interleukin 1 receptor antagonist (IL-1Ra) polymorphism was more frequent in 339 Italian MS patients than in healthy controls (HCs) (odds ratio = 1.83). A more aggressive disease course was also associated with A1+ genotypes and might reflect the reduced ability of mononuclear cell cultures of A1+ HCs to produce IL-1Ra. We conclude that an IL-1Ra gene...
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