Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.

The EMBO journal - 15 Jun 1999

Romero F, Martínez-A C, Camonis J, Rebollo A

Abstract excerpt

We searched for proteins that interact with Ras in interleukin (IL)-2-stimulated or IL-2-deprived cells, and found that the transcription factor Aiolos interacts with Ras. The Ras-Aiolos interaction was confirmed in vitro and in vivo by co-immunoprecipitation. Indirect immunofluorescence shows that IL-2 controls the cellular distribution of Aiolos and induces its tyrosine phosphorylation, required for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoplasm
Share to Guanosine Diphosphate
Share to Ikaros Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin-2

Share to Phosphotyrosine

Share to Proto-Oncogene Proteins c-bcl-2

Share to Transcriptional Activation

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 10369681
DOI: 10.1093/emboj/18.12.3419
PMCID: PMC1171421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.PMID 10369681Read ↗

Second nature: Biological functions of the Raf‐1 “kinase”Semantic proximity Read ↗

Critical role of Ras in the proliferation and prevention of apoptosis mediated by IL-2.Semantic proximity Read ↗

Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells.Semantic proximity Read ↗

A-Raf: A new star of the family of raf kinases.Semantic proximity Read ↗

The role of the Ikaros gene in lymphocyte development and homeostasis.Semantic proximity Read ↗

NF-kappaB activates Bcl-2 expression in t(14;18) lymphoma cells.Semantic proximity Read ↗

Ras signaling and NF1Semantic proximity Read ↗

FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.Semantic proximity Read ↗

Transcriptional regulation of the interleukin-11 gene by oncogenic Ras.Semantic proximity Read ↗

A genetic screen to identify novel regulators of Ikaros-mediated cell cycle arrestSemantic proximity Read ↗

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteinsSemantic proximity Read ↗

Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.