Article

A genetic screen to identify novel regulators of Ikaros-mediated cell cycle arrest

2016-01-01

Abstract excerpt

Failure to regulate cellular proliferation is one of the hallmarks of cancer. The development of pre-B cells is demarcated by alternating stages of quiescence, in which immunoglobulin receptors are sequentially rearranged, and clonal expansion, in which signals from the assembled pre-B cell receptor lead to proliferation. Ikaros (encoded by Ikzf1 in mice) is a transcription factor that regulates gene expression in...

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Literature Corpus work: fae68579-dd34-53d5-9428-3130c9fcfab8
DOI: 10.25560/31891

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