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Article

Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jun 1999

Sassa T, Harada S, Ogawa H, Rand J B, Maruyama I N, Hosono R

Abstract excerpt

The Caenorhabditis elegans unc-13, unc-18, and unc-64 genes are required for normal synaptic transmission. The UNC-18 protein binds to the unc-64 gene product C. elegans syntaxin (Ce syntaxin). However, it is not clear how this protein complex is regulated. We show that UNC-13 transiently interacts with the UNC-18-Ce syntaxin complex, resulting in rapid displacement of UNC-18 from the complex. Genetic and...

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PMID: 10366611
PMCID: PMC6782667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13.PMID 10366611Read ↗

Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.Semantic proximity Read ↗

UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.Semantic proximity Read ↗

Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.Semantic proximity Read ↗

Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin.Semantic proximity Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-13 interaction with syntaxin is required for synaptic transmission.Semantic proximity Read ↗

The Caenorhabditis elegans unc-64 locus encodes a syntaxin that interacts genetically with synaptobrevin.Semantic proximity Read ↗

Drosophila UNC-13 is essential for synaptic transmission.Semantic proximity Read ↗

The non-neuronal syntaxin SYN-1 regulates defecation behavior and neural activity in C. elegans through interaction with the Munc13-like protein AEX-1.Semantic proximity Read ↗

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.Semantic proximity Read ↗

UNC-18 modulates ethanol sensitivity in Caenorhabditis elegans.Semantic proximity Read ↗

Defects in synaptic vesicle docking in unc-18 mutants.Semantic proximity Read ↗

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