Article
Genetic factors of susceptibility and of severity in primary biliary cirrhosis.
Journal of hepatology - 1 Dec 2008
Poupon Raoul, Ping Chen, Chrétien Yves, Corpechot Christophe, Chazouillères Olivier, Simon Tabassome, Heath Simon C, Matsuda Fumihiko, Poupon Renée E, Housset Chantal, Barbu Véronique
Abstract excerpt
BACKGROUND/AIMS: In primary biliary cirrhosis (PBC), pathogenesis is influenced by genetic factors that remain poorly elucidated up to now. We investigated the impact of sequence diversity in candidate genes involved in immunity (CTLA-4 and TNFalpha), in bile formation (10 hepatobiliary transporter genes) and in the adaptative response to cholestasis (three nuclear receptor genes) on the susceptibility and...
Topics
- ATP Binding Cassette Transporter, Subfamily B
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adult
- Aged
- Anion Transport Proteins
- Antigens, CD
- Antiporters
- CTLA-4 Antigen
- Case-Control Studies