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Article

An experimental solution for the Luria-Delbrück fluctuation problem in measuring hypermutation rates.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 1999

Bachl J, Dessing M, Olsson C, von Borstel R C, Steinberg C

Abstract excerpt

A cell line harboring all trans-acting elements necessary for hypermutation was transfected with a plasmid harboring the major cis-acting elements plus a green fluorescent protein gene containing a premature chain-termination codon. Transfected cells do not fluoresce unless the stop codon reverts. When a sizable cell population is purged of revertants by sorting, the frequency of mutants increases linearly with...

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Identifiers

PMID: 10359801
DOI: 10.1073/pnas.96.12.6847
PMCID: PMC22004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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