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Article

How variable is a spontaneous mutation rate in cultured mammalian cells?

Mutation research - 1 May 1994

Boesen J J, Niericker M J, Dieteren N, Simons J W

Abstract excerpt

The Luria-Delbrück fluctuation analysis provides a method to estimate mutation rates and is commonly applied in somatic cell genetics and in cancer biology. We developed an assay for a Luria-Delbrück fluctuation analysis using the mouse lymphoma cell line, GRSL13. As these cells grow in suspension, one can handle hundreds of parallel cultures using multiwell dishes and dispensers. This assay thereby allows not...

Topics

Animals
Cell Count
Cell Division
Cells, Cultured
Culture Media, Conditioned
Lymphoma
Mammals
Mice
Mutagenicity Tests
Mutation
Tumor Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 7513788
DOI: 10.1016/0027-5107(94)90284-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7513788-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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