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Article

How variable is a spontaneous mutation rate in cultured mammalian cells?

Mutation research - 1 May 1994

Boesen J J, Niericker M J, Dieteren N, Simons J W

Abstract excerpt

The Luria-Delbrück fluctuation analysis provides a method to estimate mutation rates and is commonly applied in somatic cell genetics and in cancer biology. We developed an assay for a Luria-Delbrück fluctuation analysis using the mouse lymphoma cell line, GRSL13. As these cells grow in suspension, one can handle hundreds of parallel cultures using multiwell dishes and dispensers. This assay thereby allows not...

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PMID: 7513788
DOI: 10.1016/0027-5107(94)90284-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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