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Article

IKK-related genetic diseases: probing NF-κB functions in humans and other matters.

Cellular and molecular life sciences : CMLS - 1 Apr 2015

Senegas Anna, Gautheron Jérémie, Maurin Alice Gentil Dit, Courtois Gilles

Abstract excerpt

The transcription factor NF-κB plays a key role in numerous physiological processes such as inflammation, immunity, cell proliferation or control of cell death. Its activation is tightly controlled by a kinase complex, IκB kinase (IKK), composed of three core proteins: IKK1/IKKα, IKK2/IKKβ and NEMO/IKKγ. The first two are structurally related kinases whereas the third one is a regulatory subunit exhibiting...

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Source

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Identifiers

PMID: 25432706
DOI: 10.1007/s00018-014-1793-y
PMCID: PMC11113297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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