Article
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.
Nature - 14 Aug 2003
Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim S O, Goode J, Lin P, Mann N, Mudd S, Crozat K, Sovath S, Han J, Beutler B
Abstract excerpt
In humans, ten Toll-like receptor (TLR) paralogues sense molecular components of microbes, initiating the production of cytokine mediators that create the inflammatory response. Using N-ethyl-N-nitrosourea, we induced a germline mutation called Lps2, which abolishes cytokine responses to double-stranded RNA and severely impairs responses to the endotoxin lipopolysaccharide (LPS), indicating that TLR3 and TLR4...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.