Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.

Journal of endotoxin research - 1 Jan 2003

Hoebe Kasper, Du Xin, Goode Jason, Mann Navjiwan, Beutler Bruce

Abstract excerpt

Both forward and reverse genetic techniques have been used to define components of the mammalian lipopolysaccharide (LPS) receptor. TLR4, identified by a forward genetic approach as the product of the classical Lps locus, is the only known transmembrane component of the mammalian LPS receptor. Gene knockout work has also established that LPS signal transduction requires the integrity of CD14, MD-2, and, in part,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ethylnitrosourea
Share to Inbreeding

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lipid A

Share to Lipopolysaccharide Receptors

Share to Lipopolysaccharides

Share to Macrophage Activation

Share to Macrophages, Peritoneal

Share to Mutagens

Source

Identifiers

PMID: 12935356
DOI: 10.1179/096805103225001459

Genes

IRAK4
TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening.PMID 12935356Read ↗

Identification of Lps2 as a key transducer of MyD88-independent TIR signalling.Semantic proximity Read ↗

Tlr4: central component of the sole mammalian LPS sensor.Semantic proximity Read ↗

LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4.Semantic proximity Read ↗

Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large.Semantic proximity Read ↗

Genetic dissection of Toll-like receptor signaling using ENU mutagenesis.Semantic proximity Read ↗

CD14 is required for MyD88-independent LPS signaling.Semantic proximity Read ↗

Somatic cell genetics for the study of NF-kappaB signaling in innate immunity.Semantic proximity Read ↗

The Tpl2 mutation Sluggish impairs type I IFN production and increases susceptibility to group B streptococcal disease.Semantic proximity Read ↗

Positional cloning of Lps, and the general role of toll-like receptors in the innate immune response.Semantic proximity Read ↗

Expression level of human TLR4 rather than sequence is the key determinant of LPS responsiveness.Semantic proximity Read ↗

Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.Semantic proximity Read ↗

Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.