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Article

Requirement of the spindle checkpoint for proper chromosome segregation in budding yeast meiosis.

Science (New York, N.Y.) - 14 Jul 2000

Shonn M A, McCarroll R, Murray A W

Abstract excerpt

The spindle checkpoint was characterized in meiosis of budding yeast. In the absence of the checkpoint, the frequency of meiosis I missegregation increased with increasing chromosome length, reaching 19% for the longest chromosome. Meiosis I nondisjunction in spindle checkpoint mutants could be prevented by delaying the onset of anaphase. In a recombination-defective mutant (spo11Delta), the checkpoint delays the...

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PMID: 10894778
DOI: 10.1126/science.289.5477.300

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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