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Article

Bipolar orientation of chromosomes in Saccharomyces cerevisiae is monitored by Mad1 and Mad2, but not by Mad3.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004

Lee Marina S, Spencer Forrest A

Abstract excerpt

The spindle checkpoint governs the timing of anaphase separation of sister chromatids. In budding yeast, Mad1, Mad2, and Mad3 proteins are equally required for arrest in the presence of damage induced by antimicrotubule drugs or catastrophic loss of spindle structure. We find that the MAD genes are not equally required for robust growth in the presence of more subtle kinetochore and microtubule damage. A...

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Identifiers

PMID: 15249665
DOI: 10.1073/pnas.0404102101
PMCID: PMC489990

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