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Article

The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo

11 Jun 2007

Abstract excerpt

In addition to the ARF/p53 pathway, the DNA damage response (DDR) has been recognized as another oncogene-provoked anticancer barrier in early human tumorigenesis leading to apoptosis or cellular senescence. DDR mutations may promote tumor formation, but their impact on treatment outcome remains unclear. In this study, we generated ataxia telangiectasia mutated (Atm)-proficient and -deficient B-cell lymphomas in...

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PMID: 17562874
DOI: 10.1182/blood-2007-02-075614

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