Article
Genetic analysis of the TSH receptor gene in differentiated human thyroid carcinomas.
Journal of endocrinological investigation - 1 Apr 1999
Cetani F, Tonacchera M, Pinchera A, Barsacchi R, Basolo F, Miccoli P, Pacini F
Abstract excerpt
Somatic mutations of the TSH receptor (TSHR) gene have been identified as the major cause of toxic thyroid adenoma. Recently, point mutations of the same gene have also been described in some differentiated thyroid carcinomas. The aim of the present study was to investigate the presence TSHR gene mutations in a series of thyroid specimens obtained from 22 consecutive patients with differentiated thyroid...
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