Article
Structural studies of the thyrotropin receptor and Gs alpha in human thyroid cancers: low prevalence of mutations predicts infrequent involvement in malignant transformation.
The Journal of clinical endocrinology and metabolism - 1 Nov 1996
Spambalg D, Sharifi N, Elisei R, Gross J L, Medeiros-Neto G, Fagin J A
Abstract excerpt
The genes for either the TSH receptor (TSH-R) or the stimulatory guanine nucleotide-binding protein subunit (Gs alpha) can undergo somatic mutations in thyroid cells, leading to constitutive activation of adenylyl cyclase and the formation of clonal hyperfunctioning thyroid adenomas. Autonomously...
Topics
- Base Sequence
- Cell Differentiation
- Cell Transformation, Neoplastic
- Codon
- DNA Primers
- DNA, Neoplasm
- Female
- GTP-Binding Protein alpha Subunits, Gs
- Humans
- Male
- Middle Aged
- Molecular Structure
- Mutation
- Point Mutation