Article
Genetic alterations in thyroid hyperfunctioning adenomas.
The Journal of clinical endocrinology and metabolism - 1 Apr 1995
Russo D, Arturi F, Wicker R, Chazenbalk G D, Schlumberger M, DuVillard J A, Caillou B, Monier R, Rapoport B, Filetti S
Abstract excerpt
Thirty-seven thyroid autonomously hyperfunctioning adenomas were screened for mutations in the TSH receptor (TSHR), G alpha s (gsp), and ras genes. Polymerase chain reaction-amplified fragments of the TSHR C-terminal part (exon 10), the G alpha s (exons 8 and 9), and the three ras genes were obta...
Topics
- Adenoma
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- Genes, ras
- Humans
- Molecular Probes
- Molecular Sequence Data
- Mutation
- Receptors, Thyrotropin
- Thyroid Gland
- Thyroid Neoplasms