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Article

The extracellular thyrotropin receptor domain is not a major candidate for mutations in toxic thyroid nodules.

Thyroid : official journal of the American Thyroid Association - 1 Nov 1998

Führer D, Kubisch C, Scheibler U, Lamesch P, Krohn K, Paschke R

Abstract excerpt

Constitutive activation of the cyclic adenosine monophosphate (cAMP) cascade by either thyrotropin receptor (TSHR) or gsp mutations is considered to be the major molecular cause of toxic thyroid nodules (TTNs). In a recent study we investigated a consecutive series of 31 TTNs and identified 15 so...

Topics

Amino Acid Sequence
Base Sequence
Codon
Extracellular Space
Humans
Mutation
Polymorphism, Genetic
Receptors, Thyrotropin
Thyroid Nodule

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9848712
DOI: 10.1089/thy.1998.8.997

Genes

TSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9848712-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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The extracellular thyrotropin receptor domain is not a major candidate for mutations in toxic thyroid nodules.PMID 9848712Read ↗

Somatic mutations in the thyrotropin receptor gene and not in the Gs alpha protein gene in 31 toxic thyroid nodules.Semantic proximity Read ↗

Non-hyperfunctioning nodules from multinodular goiters: a minor role in pathogenesis for somatic activating mutations in the TSH-receptor and Gsalpha subunit genes.Semantic proximity Read ↗

Detection of thyroid-stimulating hormone receptor and Gsalpha mutations: in 75 toxic thyroid nodules by denaturing gradient gel electrophoresis.Semantic proximity Read ↗

Genetic analysis of the TSH receptor gene in differentiated human thyroid carcinomas.Semantic proximity Read ↗

Identification of constitutively activating somatic thyrotropin receptor mutations in a subset of toxic multinodular goiters.Semantic proximity Read ↗

Diversity and prevalence of somatic mutations in the thyrotropin receptor and Gs alpha genes as a cause of toxic thyroid adenomas.Semantic proximity Read ↗

Thyrotropin receptor mutations as a tool to understand thyrotropin receptor action.Semantic proximity Read ↗

Activating mutations of the TSH receptor gene cause thyroid diseases.Semantic proximity Read ↗

Shared sporadic and somatic thyrotropin receptor mutations display more active in vitro activities than familial thyrotropin receptor mutations.Semantic proximity Read ↗

A novel activating mutation in the thyrotropin receptor gene in an autonomously functioning thyroid nodule developed by a Japanese patient.Semantic proximity Read ↗

Two novel mutations in the sixth transmembrane segment of the thyrotropin receptor gene causing hyperfunctioning thyroid nodules.Semantic proximity Read ↗

Identification and functional characterization of two novel activating thyrotropin receptor mutants in toxic thyroid follicular adenomas.Semantic proximity Read ↗

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