Article
The extracellular thyrotropin receptor domain is not a major candidate for mutations in toxic thyroid nodules.
Thyroid : official journal of the American Thyroid Association - 1 Nov 1998
Führer D, Kubisch C, Scheibler U, Lamesch P, Krohn K, Paschke R
Abstract excerpt
Constitutive activation of the cyclic adenosine monophosphate (cAMP) cascade by either thyrotropin receptor (TSHR) or gsp mutations is considered to be the major molecular cause of toxic thyroid nodules (TTNs). In a recent study we investigated a consecutive series of 31 TTNs and identified 15 somatic TSHR mutations (n = 14 in exon 10; n = 1 in exon 9) but no mutations in gsp exons 7-10. The purpose of the...
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