Article
Sto1p, a fission yeast protein similar to tubulin folding cofactor E, plays an essential role in mitotic microtubule assembly.
Journal of cell science - 1 Jun 1999
Grishchuk E L, McIntosh J R
Abstract excerpt
The proper functioning of microtubules depends crucially on the availability of polymerizable alpha/beta tubulin dimers. Their production occurs concomitant with the folding of the tubulin polypeptides and is accomplished in part by proteins known as Cofactors A through E. In the fission yeast, Schizosaccharomyces pombe, this tubulin folding pathway is essential. We have taken advantage of the excellent cytology...
Topics
- Amino Acid Sequence
- Cell Division
- Cells, Cultured
- Fungal Proteins
- Gene Deletion
- Gene Expression Regulation, Fungal
- Microtubules
- Mitosis
- Molecular Sequence Data
- Phenotype
- Protein Folding
- Schizosaccharomyces
- Schizosaccharomyces pombe Proteins
- Sequence Homology, Amino Acid
- Tubulin
