Article
Characterisation of fission yeast alp11 mutants defines three functional domains within tubulin-folding cofactor B.
Molecular & general genetics : MGG - 1 Jun 2000
Radcliffe P A, Toda T
Abstract excerpt
The proper folding of tubulins prior to their incorporation into microtubules requires a group of conserved proteins called cofactors A to E. In fission yeast, homologues of these cofactors (at least B, D and E) are necessary for the biogenesis of microtubules and for cell viability. Here we show that the temperature-sensitive alp11-924 mutant, which is defective in the cofactor B homologue, contains an opal...
Topics
- Amino Acid Sequence
- Base Sequence
- Chaperonins
- Fungal Proteins
- Genes, Fungal
- Microtubules
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Folding
- Protein Structure, Tertiary