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Article

An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue.

Molecular biology of the cell - 1 Jun 2018

Majumdar Shreoshi, Kim Tae, Chen Zhe, Munyoki Sarah, Tso Shih-Chia, Brautigam Chad A, Rice Luke M

Abstract excerpt

Microtubules are heavily regulated dynamic polymers of αβ-tubulin that are required for proper chromosome segregation and organization of the cytoplasm. Polymerases in the XMAP215 family use arrayed TOG domains to promote faster microtubule elongation. Regulatory factors in the cytoplasmic linker associated protein (CLASP) family that reduce catastrophe and/or increase rescue also contain arrayed TOGs, but how...

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Identifiers

PMID: 29851564
DOI: 10.1091/mbc.E17-12-0748
PMCID: PMC5994897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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