Article
Myeloid malignancies induced by alkylating agents in Nf1 mice.
Blood - 1 Jun 1999
Mahgoub N, Taylor B R, Le Beau M M, Gratiot M, Carlson K M, Atwater S K, Jacks T, Shannon K M
Abstract excerpt
Therapy-related acute myeloid leukemia and myelodysplastic syndrome (t-AML and MDS) are severe late complications of treatment with genotoxic chemotherapeutic agents. Children with neurofibromatosis type 1 (NF1) are predisposed to malignant myeloid disorders that are associated with inactivation of the NF1 tumor suppressor gene in the leukemic clone. Recent clinical data suggest that NF1 might be also associated...
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