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Article

Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice

10 Dec 2012

Abstract excerpt

Children with neurofibromatosis type 1 (NF1) are predisposed to juvenile myelomonocytic leukemia (JMML), an aggressive myeloproliferative neoplasm (MPN) that is refractory to conventional chemotherapy. Conditional inactivation of the Nf1 tumor suppressor in hematopoietic cells of mice causes a progressive MPN that accurately models JMML and chronic myelomonocytic leukemia (CMML). We characterized the effects of...

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PMID: 23221337
DOI: 10.1172/jci63193

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