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Article

Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders.

The New England journal of medicine - 12 Jun 1997

Side L, Taylor B, Cayouette M, Conner E, Thompson P, Luce M, Shannon K

Abstract excerpt

BACKGROUND: The risk of malignant myeloid disorders in young children with neurofibromatosis type 1 is 200 to 500 times the normal risk. The gene for neurofibromatosis type 1 (NF1) encodes neurofibromin, a protein that negatively regulates signals transduced by Ras proteins. Genetic and biochemical data support the hypothesis that NF1 functions as a tumor-suppressor gene in immature myeloid cells, but...

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Source

Identifiers

PMID: 9180088
DOI: 10.1056/NEJM199706123362404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders.PMID 9180088Read ↗

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Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders.Semantic proximity Read ↗

Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1.Semantic proximity Read ↗

The Role of RUNX1 in NF1-Related Tumors and Blood Disorders.Semantic proximity Read ↗

Genetic and Biochemical Evidence That Haploinsufficiency of the Nf1 Tumor Suppressor Gene Modulates Melanocyte and Mast Cell Fates in VivoSemantic proximity Read ↗

Mitotic recombination and compound-heterozygous mutations are predominant NF1-inactivating mechanisms in children with juvenile myelomonocytic leukemia and neurofibromatosis type 1.Semantic proximity Read ↗

Biallelic inactivation of the NF1 tumour suppressor gene in juvenile myelomonocytic leukaemia: Genetic evidence of driver function and implications for diagnostic workup.Semantic proximity Read ↗

Molecular basis of neurofibromatosis type 1 (NF1): mutation analysis and polymorphisms in the NF1 gene.Semantic proximity Read ↗

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