Article
Retroviral integration at the Epi1 locus cooperates with Nf1 gene loss in the progression to acute myeloid leukemia.
Journal of virology - 1 Oct 2001
Blaydes S M, Kogan S C, Truong B T, Gilbert D J, Jenkins N A, Copeland N G, Largaespada D A, Brannan C I
Abstract excerpt
Juvenile myelomonocytic leukemia (JMML) is a disease that occurs in young children and is associated with a high mortality rate. In most patients, JMML has a progressive course leading to death by virtue of infection, bleeding, or progression to acute myeloid leukemia (AML). As it is known that children with neurofibromatosis type 1 syndrome have a markedly increased risk of developing JMML, we have previously...
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