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Article

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

1 Mar 2004

Abstract excerpt

The NF1 tumor suppressor gene encodes a guanosine triphosphotase (GTPase)-activating protein that negatively regulates Ras signaling and is inactivated in a subset of juvenile myelomonocytic leukemias (JMMLs). Adoptive transfer of fetal liver cells from Nf1 mutant mice models JMML; however, this system has important limitations as a platform for performing biologic and preclinical studies. We have exploited the...

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Identifiers

PMID: 14982883
DOI: 10.1182/blood-2003-08-2650

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