Article
A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants.
Nature - 13 May 1999
Taub J, Lau J F, Ma C, Hahn J H, Hoque R, Rothblatt J, Chalfie M
Abstract excerpt
The dauer larva is an alternative larval stage in Caenorhabditis elegans which allows animals to survive through periods of low food availability. Well-fed worms live for about three weeks, but dauer larvae can live for at least two months without affecting post-dauer lifespan. Mutations in daf-2 and age-1, which produce a dauer constitutive (Daf-C) phenotype, and in clk-1, which are believed to slow metabolism,...
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