Article
No reduction of energy metabolism in Clk mutants.
Mechanisms of ageing and development - 1 Sept 2002
Braeckman Bart P, Houthoofd Koen, Brys Kristel, Lenaerts Isabelle, De Vreese Annemie, Van Eygen Sylvie, Raes Hilda, Vanfleteren Jacques R
Abstract excerpt
Mutation in any of the four clock genes (clk-1, clk-2, clk-3, gro-1) causes an average slowing down of many temporal processes, and an increase of mean life span. The latter effect has been linked to the slow phenotype, and it has been reasoned that any reduction of the rate of living would reduce the load of oxidative damage, which is thought to drive the ageing process. To test this model we measured several...
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