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Article

Enhanced oxidative stress resilience in C. elegans acox-1.1 mutants through CTL-3 and proteasomal regulation.

Experimental biology and medicine (Maywood, N.J.) - 1 Jan 2026

Bae Woori, Norman Mina, Lee Myon Hee

Abstract excerpt

Oxidative stress is a primary driver of aging, necessitating robust cellular adaptation mechanisms. While peroxisomal β-oxidation and proteasomal degradation are known to influence stress responses, their functional crosstalk remains elusive. In this study, we show that C. elegans acox-1.1 mutants, despite having a shortened lifespan under normal conditions, exhibit a paradoxical resistance to mild chronic...

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Identifiers

PMID: 41908884
DOI: 10.3389/ebm.2026.10796
PMCID: PMC13021563

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