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Article

Tracing the origin of HLA-DRB1 alleles by microsatellite polymorphism.

American journal of human genetics - 1 Jun 1999

Bergström T F, Engkvist H, Erlandsson R, Josefsson A, Mack S J, Erlich H A, Gyllensten U

Abstract excerpt

We analyzed the origin of allelic diversity at the class II HLA-DRB1 locus, using a complex microsatellite located in intron 2, close to the polymorphic second exon. A phylogenetic analysis of human, gorilla, and chimpanzee DRB1 sequences indicated that the structure of the microsatellite has evolved, primarily by point mutations, from a putative ancestral (GT)x(GA)y-complex-dinucleotide repeat. In all...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10330359
DOI: 10.1086/302401
PMCID: PMC1377915

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Tracing the origin of HLA-DRB1 alleles by microsatellite polymorphism.PMID 10330359Read ↗

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Evolutionary relationship of HLA-DRB genes inferred from intron sequences.Semantic proximity Read ↗

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