Evolutionary relationship of HLA-DRB genes inferred from intron sequences.

doi:10.1007/BF02338798

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Article

Evolutionary relationship of HLA-DRB genes inferred from intron sequences.

Journal of molecular evolution - 1 Jun 1996

Satta Y, Mayer W E, Klein J

Abstract excerpt

The major histocompatibility complex (Mhc) consists of class I and class II genes. In the human Mhc (HLA) class II genes, nine DRB loci have been identified. To elucidate the origin of these duplicated loci and allelic divergences at the most polymorphic DRB1 locus, introns 4 and 5 as well as the...

Topics

Alleles
Animals
Base Sequence
Evolution, Molecular
Genetic Markers
HLA-DR Antigens
HLA-DRB1 Chains
Humans
Introns
Major Histocompatibility Complex
Molecular Sequence Data
Multigene Family
Phylogeny
Primates
Sequence Alignment
Sequence Homology, Nucleic Acid

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