Evolution of the human HLA-DR region

Abstract excerpt

The genomic organization and number of human HLA-DRB class II genes differs between haplotypes in the human population. In contrast, both HLA-DQ and -DP class II subregions are conserved. Understanding of the evolutionary relationship and age of HLA-DR haplotypes has been obtained by nucleotide sequence determination and phylogenetic analyses of intron sequences of all known DRB genes from different DR...

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