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Article

Mutations which alter the elbow region of tRNA2Gly reduce T4 gene 60 translational bypassing efficiency.

The EMBO journal - 17 May 1999

Herr A J, Atkins J F, Gesteland R F

Abstract excerpt

Translating ribosomes bypass a 50 nucleotide coding gap in bacteriophage T4 gene 60 mRNA between codons 46 and 47 in order to synthesize the full-length protein. Bypassing of the coding gap requires peptidyl-tRNA2Gly detachment from a GGA codon (codon 46) followed by re-pairing at a matching GGA codon just before codon 47. Using negative selection, based on the sacB gene from Bacillus subtilis, Escherichia coli...

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Identifiers

PMID: 10329634
DOI: 10.1093/emboj/18.10.2886
PMCID: PMC1171369

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