Article
Importance of the reverse Hoogsteen base pair 54-58 for tRNA function.
Nucleic acids research - 15 Jul 2003
Zagryadskaya Ekaterina I, Doyon Felix R, Steinberg Sergey V
Abstract excerpt
To elucidate the general constraints imposed on the structure of the D- and T-loops in functional tRNAs, active suppressor tRNAs were selected in vivo from a combinatorial tRNA gene library in which several nucleotide positions of these loops were randomized. Analysis of the nucleotide sequences of the selected clones demonstrates that among the randomized nucleotides, the most conservative are nucleotides 54 and...
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